Synthesis,Characterization and Antimicrobial Evolution of New Bi-α-amino Nitrile Compounds

This project is regarding the synthesis of new bi-α-amino nitrile compounds derived from the reaction of di-amine , aldehyde (vanillin oro-vanillin ),and KCN in glacial acetic acid as a solvent . The three components-one pot reaction produced (2,2'-(1,2-phenylenebis(azanediyl))bis(2-(4-hydroxy-3-methoxyphenyl)acetonitrile) (I) and(2,2'-(1,2-phenylenebis(azanediyl))bis(2-(2-hydroxy-3-methoxyphenyl)acetonitrile) (II)considering the formation of bi-imine compounds as intermediate. α-amino nitrile compounds (I and II) were characterized using infrared spectroscopy and mass spectroscopy. The prepared compounds were screened for their anti-microbialactivity. The bacteria are Gram positive (Staphylococcus aurous) and Gram negative (Escherichia coli) in vitro, the results were promising; due to the large inhibition zones.