Coronary atherosclerotic plaque burden and composition by CT angiography in Caucasian and South Asian patients with stable chest pain
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Key result
South Asian patients with stable chest pain had a significantly higher non-calcified coronary plaque composition compared with Caucasian patients (90.42% vs. 80.95%, p<0.001).
Why the study?
Does South Asian ethnicity compared to Caucasian ethnicity affect coronary atherosclerotic plaque burden and composition in patients with stable chest pain?
Population
963 consecutive Caucasian and South Asian patients with stable chest pain undergoing coronary computed…
Comparison
South Asian ethnicity vs Caucasian ethnicity
Design
Cross-sectional
Authors
Discussion
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Implication
May contribute to excess events in South Asians; hypothesis-generating for ethnicity-specific risk models pending prospective validation.
Study Design
Type
Cross-Sectional (n=963)
Multicenter
No
Structured PICO
Does South Asian ethnicity compared to Caucasian ethnicity affect coronary atherosclerotic plaque burden and composition in patients with stable chest pain?
P
Population
963 Caucasian and South Asian patients with stable chest pain undergoing coronary computed tomography angiography in a non-acute setting.
E
Exposure
South Asian ethnicity
C
Comparator
Caucasian ethnicity
O
Outcome
Prevalence of coronary stenoses, amount and composition of coronary atherosclerosis (calcified, non-calcified, and total plaque burden) measured by CT angiographysurrogate
Main Result
Absolute Event Rate: 90.42% vs 80.95%
p-value: p=<0.001
South Asian patients with stable chest pain have a higher proportion of non-calcified coronary plaque compared to Caucasians, independent of traditional cardiovascular risk factors, which may contribute to their higher risk of acute cardiovascular events.
Limitations
- Cross-sectional design without clinical outcome data
- Potential residual confounding factors such as physical activity, diet, and socioeconomic status
- Reduced statistical power after propensity score exact matching
- Potential selection bias due to earlier referral of South Asian patients
- Single-center study limiting generalizability
Cite This Study
Villadsen et al. (2016) conducted a cross-sectional in Stable chest pain (n=963). South Asian ethnicity vs. Caucasian ethnicity was evaluated on Per cent non-calcified plaque composition (p=<0.001). South Asian patients with stable chest pain had a significantly higher non-calcified coronary plaque composition compared with Caucasian patients (90.42% vs. 80.95%, p<0.001).
Topics
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