Key result
Preoperative frailty linked to ~87% higher risk of severe complications and mortality after radical prostatectomy.
Why the study?
The study was conducted to investigate the association between frailty and postoperative complications in patients with prostate cancer following radical prostatectomy.
Does frailty predict severe postoperative complications and all-cause mortality in patients with prostate cancer receiving radical prostatectomy?
Meta-Analysis (n=171,929)
Does frailty predict severe postoperative complications and all-cause mortality in patients with prostate cancer receiving radical prostatectomy?
Relative Risk: 1.87 (95% CI 1.67–2.1)
p-value: p=< .001
Preoperative frailty is a significant predictor of severe postoperative complications and all-cause mortality in patients undergoing radical prostatectomy for prostate cancer.
Frailty screening may refine preoperative risk stratification for radical prostatectomy; leaves open whether interventions improve outcomes.
A meta-analysis was conducted to investigate the association between frailty and postoperative complications in patients with prostate cancer following radical prostatectomy. A systematic search of PubMed, Embase, and Web of Science was conducted for relevant cohort studies. A random-effect model was chosen to combine the results. Five cohort studies including 171,929 patients were included. Results showed that patients with frailty had higher risk of severe postoperative complications (Clavien-Dindo IV complications, risk ratio [RR]: 1.87, 95% confidence interval [CI]: 1.67 to 2.10, p < .001; I 2 = 18%) and all-cause mortality (RR: 2.89, 95% CI: 1.86 to 4.50, p < 0.001; I 2 = 18%). Subgroup analyses showed consistent results in patients receiving open and robot-assisted radical prostatectomy, and also in studies with univariate and multivariate analyses. In conclusion, preoperative frailty may be a predictor of severe postoperative complications and all-cause mortality of patients with prostate cancer following radical prostatectomy.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2022) conducted a meta-analysis in prostate cancer (n=171,929). Frailty was evaluated on severe postoperative complications (Clavien-Dindo IV complications) (RR 1.87, 95% CI 1.67 to 2.10, p=< .001). Preoperative frailty was associated with a higher risk of severe postoperative complications (RR 1.87; 95% CI 1.67-2.10; p<0.001) and all-cause mortality after radical prostatectomy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: