Why the study?
Door-in to door-out time may affect STEMI patient prognosis, but a relevant meta-analysis was lacking.
Does a door-in to door-out (DIDO) time ≤30 minutes reduce in-hospital or 30-day mortality in STEMI patients transferred for primary PCI compared to a DIDO time >30 minutes?
Meta-Analysis (n=15,596)
Yes
Does a door-in to door-out (DIDO) time ≤30 minutes reduce in-hospital or 30-day mortality in STEMI patients transferred for primary PCI compared to a DIDO time >30 minutes?
Achieving a door-in to door-out (DIDO) time of ≤30 minutes for STEMI patients transferred for primary PCI is associated with significantly lower short-term mortality.
Supports DIDO ≤30 min targets in transferred STEMI; reinforces guidelines and warrants implementation trials.
Background:Primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is now widely accepted. Recent guidelines have focused on total ischemic time, because shorter total ischemic time is associated with a more favorable prognosis. The door-in to door-out (DIDO) time, defined as time from arrival at a non-PCI-capable hospital to leaving for a PCI-capable hospital, may affect STEMI patient prognosis. However, a relevant meta-analysis is lacking.
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A 2022 study conducted a meta-analysis in ST-elevation myocardial infarction (STEMI) (n=15,596). Door-in to door-out (DIDO) time ≤30 min vs. DIDO time >30 min was evaluated on In-hospital or 30-day mortality (OR 0.45, 95% CI 0.34-0.60).
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