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We followed 191 normal glucose tolerant (NGT; 1985 World Health Organization criteria) nondiabetic subjects (115 men) as control subjects in the Wellcome Diabetes Study (1). Their mean age was 41 years (SD 11.2), BMI 23.6 kg/m2 (34% >25 kg/m2), and 31% had a first-degree relative with diabetes. During the next 10 years, 8 (7 men) died, 40 were lost to follow up, 14 men and 8 women became impaired glucose tolerant (IGT), and 2 men and 4 women developed diabetes. Men whose glucose tolerance deteriorated were heavier at entry …
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Yajnik et al. (2003) studied this question.
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