Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients

Figures

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  Figure 1. Occurrence ratios in the CES1 S75N genotype group. Fourteen percent of CC group patients and 4.8% of CT + TT group patients had cerebrovascular events after clopidogrel treatment (p < 0.001). 15.1% vs 6.1% of patients suffered acute myocardial infarction and 62.8% vs 37.7% suffered unstable angina after treatment, respectively (p < 0.001). The total number of patients in the CC and CT + TT groups was 471 and 374, respectively.

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  Figure 2. Association between genetic polymorphisms and clinical outcomes in acute coronary syndrome patients. Each box and horizontal line represents the odds ratio (OR) and 95% confidence interval (CI); each analysis used the C allele for reference. Eight factors were included in the analysis and all factors were adjusted for the other factors. For example, when analyzing age, the factors, including gender, smoke state, plant stent, hypertension, hyperlipemia, diabetes, BBC and PPI were adjusted.