Neuroprotective Effects of Curcuma Longa on Pentylenetetrazole-Induced Neurotoxicity on the Cerebrum and Hippocampus of Albino Wistar Rats

Epilepsy is a neurological disorder characterized by recurrent seizures, and current anti-epileptic drugs often have side effects. Curcuma longa, commonly known as turmeric, has been traditionally used for various medicinal purposes, including the treatment of neurological disorders. This study investigates the neuroprotective effects of Curcuma longa in pentylenetetrazol (PTZ)-induced epilepsy in albino rats. Group one received normal feed (control). Group two received PTZ to induce epilepsy intraperitoneally. Group three received PTZ with feed. Group four received a low dose of Curcuma longa with PTZ, and Group five received a high dose of Curcuma longa with PTZ. The experiment lasted for 28 days, during which seizure severity and neurotoxicity were assessed. The results revealed that PTZ administration significantly increased seizure severity and frequency, as well as oxidative stress and neuroinflammatory markers. Treatment with Curcuma longa extract, particularly at the low dose and high dose, significantly reduced oxidative stress and neuroinflammation and improved neuroprotection. These findings suggest that Curcuma longa extract may have potential neuroprotective effects and anticonvulsant properties, making it a promising candidate for adjunctive therapy in epilepsy management.