Key result
Maternal smoking during pregnancy was significantly associated with an increased risk of cardiovascular malformations in newborns (OR 4.09; 95% CI 1.75-9.53).
Observational (n=28,511)
Yes
Odds Ratio: 4.09 (95% CI 1.75–9.53)
Maternal smoking and previous stillbirth are strongly associated with cardiovascular malformations in newborns, highlighting key targets for public health intervention.
BACKGROUND: Cardiovascular malformations (CVM) are one of the most prevalent groups of birth defects. Knowledge about the prevalence, distribution and survival in Russia has been limited. The aim of our study was to assess the perinatal prevalence, structure and risk factors for CVM among newborns in Monchegorsk (Murmansk Oblast, Russia) and the mortality among the affected newborns in the period 1973-2008. DESIGN AND METHODS: A register-based study on data from the Kola and Murmansk County Birth Registers. The study included 28,511 births. RESULTS: The registered perinatal prevalence was 3.0 per 1000 new-borns, with septal defects as the most prevalent. CVM was twenty times more prevalent among stillborn than live born, and one-third of the live born with a CVM died during the first week of life. The perinatal mortality rate with CVM was 442 per 1000 newborns. This indicator decreased over time. The mothers of newborns with a CVM were ten times more likely to have stillbirth in their anamnesis. The adjusted odds ratio between maternal smoking during pregnancy and CVM was 4.09 [95% confidence interval: 1.75-9.53]. CONCLUSIONS: The diagnosed perinatal prevalence was relatively low. A previous stillbirth by the mother was highly associated with being born with a CVM. An adjusted elevated risk was also observed among smoking mothers. Perinatal survival increased over time, but varied to a large extent between the different types of CVM. Significance for public healthCardiovascular malformation is one of the most common groups of birth defects. It is considered an important public health issue, as these malformations are the main cause of infant deaths in developed countries. Precise estimates about the prevalence and perinatal survival are needed to organise and plan health care for such newborns. Our study is the first report from the Russian Federation based on data from population-based birth registers.
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Postoev et al. (2014) conducted an observational in Cardiovascular malformations (n=28,511). Maternal smoking during pregnancy vs. Non-smoking mothers was evaluated on Cardiovascular malformations (OR 4.09, 95% CI 1.75-9.53). Maternal smoking during pregnancy was significantly associated with an increased risk of cardiovascular malformations in newborns (OR 4.09; 95% CI 1.75-9.53).
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