Solid support synthesis of a PNA‐DNA hybrid

The solid support synthesis of a homothymine PNA‐DNA octamer (i.e. hybrid 13) could be realized using tetrabutylammonium N‐(2‐(4‐methoxytrityl)‐aminoethyl)‐N‐((thymin‐1‐yl)acetyl)glycinate as PNA building block and the respective 2‐cyanoethyl‐N,N‐diisopropylphosphoramidite derivatives of both 5′‐O‐(4,4′‐dimethoxytrityl)thymidine and 5′‐N‐(4‐methoxytrityl)amino‐5′‐deoxythymidine.