Key result
Risk-stratified weaning cuts opioid duration ~37% and reduces benzodiazepine use in critically ill cardiac children.
Why the study?
Does a risk-stratified opioid and benzodiazepine weaning protocol reduce the duration of opioid and benzodiazepine exposure and withdrawal symptoms in critically ill pediatric patients with cardiac disease?
Does a risk-stratified opioid and benzodiazepine weaning protocol reduce the duration of opioid and benzodiazepine exposure and withdrawal symptoms in critically ill pediatric patients with cardiac disease?
Absolute Event Rate: 19% vs 30%
p-value: p=< 0.01
Implementation of a risk-stratified weaning protocol significantly reduces opioid and benzodiazepine exposure, withdrawal symptoms, and hospital length of stay in pediatric cardiac ICU patients.
Risk-stratified weaning was associated with shorter opioid and benzodiazepine exposure in pediatric cardiac ICU patients; leaves open confirmation in randomized trials.
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Amirnovin et al. (2018) studied Critically ill children with cardiac disease exposed to opioids and benzodiazepines (n=119). Risk-stratified opioid and benzodiazepine weaning protocol vs. Pre-intervention standard care was evaluated on Duration of opioids (p=< 0.01). Implementation of a risk-stratified weaning protocol reduced the duration of opioids (19.0 vs 30.0 days; p<0.01) and benzodiazepines (5.3 vs 22.7 days; p<0.01) in critically ill cardiac children.
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