Key result
CACS and CIMT moderately correlate with CAD severity on SYNTAX score.
Why the study?
Although CACS and CIMT are established markers of CAD, their relationship with CAD severity remains less clear.
Do coronary artery calcium score and carotid artery intima-media thickness correlate with the angiographic severity of coronary artery disease?
Observational (n=351)
Single-blind
No
Do coronary artery calcium score and carotid artery intima-media thickness correlate with the angiographic severity of coronary artery disease?
Effect estimate: r=0.417
p-value: p=<0.0001
Coronary artery calcium score and carotid artery intima-media thickness significantly correlate with the angiographic severity of coronary artery disease, supporting their utility as noninvasive diagnostic markers.
May aid noninvasive CAD severity assessment; leaves open incremental value and prospective validation.
Introduction : Coronary artery calcium score (CACS) and carotid artery intima-media thickness (CIMT) are the markers of atherosclerosis. An association between CACS and CIMT with presence of atherosclerotic coronary artery disease (CAD) is well established. However relationship between severity of CAD with CACS and CIMT is less clear. This study aimed to investigate the correlation between severity of CAD assessed by SYNTAX and Gensini scores with CACS and CIMT. Methods: This prospective study was conducted on 351 patients with CAD between June 2015 to December 2016. CACS was obtained using AGATSTON algorithm with 128 slice multidetector computer tomography (MDCT) before conventional coronary angiography (CCA). CIMT was measured by using Philips IE33 Echo machine. The severity of CAD was assessed by SYNTAX score (SS) and Gensini score on CCA. Correlation between severity of CAD with CACS and CIMT was analysed. Results: Mean CACS was 241.5±463.7, and this was positively correlated with over all SS (r=0.417, P<0.0001) and Gensini score (r=0.405, P<0.0001). Mean CIMT was 0.80±0.18 mm and this was also significantly correlated with SS (r=0.450, P<0.0001) and Gensini score (r=0.459,<0.0001). Multivariate analysis showed that CACS was independently associated with diabetes mellitus (β:0.11, P=0.021), SS (β:0.251, P=0.010) and mean CIMT (β:0.128, P=0.028). Receiver-operating characteristic (ROC) curve analysis revealed a cut off CACS of >493 for SS≥33 (high-SS tertile). Conclusion: Our study confirmed a significant correlation between CACS and CIMT with the severity of CAD assessed by SS and Gensini scores. CACS and CIMT may be considered as important noninvasive diagnostic modalities in the assessment of the severity of CAD.
No takes yet. Share an insight, caveat, or question.
Pathakota et al. (2020) conducted an observational in Coronary artery disease (n=351). Coronary artery calcium score (CACS) and carotid artery intima-media thickness (CIMT) was evaluated on Correlation of CACS with SYNTAX score (r=0.417, p=<0.0001). Coronary artery calcium score and carotid intima-media thickness were significantly correlated with the severity of coronary artery disease assessed by SYNTAX score (r=0.417 and r=0.450, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: