The fatty acid composition of plasma, liver, adipose tissue and carcass NFFA, FFA and PLFA have been studied in normal and ethionine‐treated fasted female rats. The fatty acid composition of adipose tissue and carcass lipids and also that of plasma FFA were uninfluenced by ethionine‐treatment. Thus, there was no sign of any qualitative difference in the mobilization of fatty acids from the depots in the ethionine‐treated rats. The fatty acid composition of liver NFFA and PLFA and of plasma TGFA, CEFA and PLFA on the other hand were significantly changed by ethionine‐treatment. In the normal rats most of the ratios between the fatty acids were different in liver NFFA and adipose tissue NFFA. In the ethionine‐treated rats the ratios not containing linoleic acid were not significantly different in liver NFFA and adipose tissue NFFA. This agreement is taken as evidence for adipose tissue NFFA being the source of the increased liver NFFA. As linoleic acid cannot be synthesized in the rat, the linoleic acid, which was present in the accumulated liver NFFA in an even higher percentage than in adipose tissue NFFA, must also have derived from an extrahepatic tissue, most probably adipose tissue.
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Arvidson et al. (1962) studied this question.
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