Key result
Early seizure duration increases during maintenance ECT are linked to non-response and relapse.
Why the study?
Does the change in seizure duration during maintenance electroconvulsive therapy predict clinical response?
Cohort
Does the change in seizure duration during maintenance electroconvulsive therapy predict clinical response?
An early increase in seizure duration at constant energy during maintenance electroconvulsive therapy may be predictive of relapse.
May signal relapse risk in maintenance ECT; hypothesis-generating and should not yet change practice.
Acute electroconvulsive therapy has anticonvulsive effects. The aim of the present study was to investigate the anticonvulsive efficiency of maintenance electroconvulsive therapy. Records of patients treated with maintenance electroconvulsive therapy were screened retrospectively, and the changes in seizure duration were measured. The patients were subdivided into responders and non-responders. Responders had no significant seizure duration changes within the first week of maintenance electroconvulsive therapy. In contrast, the seizure duration of the non-responder group increased significantly within the first week. It was concluded that the early increase in seizure duration at constant energy could be predictive of relapse.
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Pauli et al. (2009) conducted a cohort in Patients requiring maintenance electroconvulsive therapy. Early increase in seizure duration vs. No significant change in seizure duration was evaluated on Relapse (non-response to maintenance electroconvulsive therapy). An early increase in seizure duration at constant energy during the first week of maintenance electroconvulsive therapy was significantly associated with non-response and could predict relapse.
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