Key result
Clavien-Dindo and CTCAE systems similarly rate complications, both linking open surgery to ~8-fold higher risk.
Why the study?
The study aimed to compare early complication rates, complication risk factors, and length of hospital stay in colorectal cancer surgery patients using Clavien-Dindo versus CTCAE classifications.
Does the Clavien-Dindo classification compare favorably to the CTCAE classification in grading postoperative early-stage complications in patients with colorectal cancer?
Cohort (n=222)
Does the Clavien-Dindo classification compare favorably to the CTCAE classification in grading postoperative early-stage complications in patients with colorectal cancer?
Both Clavien-Dindo and CTCAE classification systems are equally effective for grading postoperative complications in colorectal cancer patients.
Answers are grounded in this paper and cite their sources.
Both systems grade colorectal surgery complications comparably; observational data leave open which to prefer in practice.
Introduction: The present study aimed to compare early complication rates, risk factors for complications, and hospital stay lengths in patients operated on for Colorectal cancer, by using Clavien-Dindo and Common Terminology Criteria for Adverse Events (CTCAE) complication classifications.Materials and methods: 222 patients who were operated between March 2019 and June 2020 with the diagnosis of colorectal cancer and had early complications were evaluated retrospectively.Complications that developed in the early postoperative period were graded according to Clavien-Dindo and CTCAE classifications.The effects of demographic data, surgical technique, tumor location, neoadjuvant chemoradiotherapy history, preoperative transfusion history, urgency of the operation, additional organ resection, co-morbid diseases, pathological stage and duration of surgery on complications were compared.Results: According to the Clavien-Dindo classification, the risk of developing complications was 3 times higher in male gender, 8 times higher in open surgical intervention, and 1.7 times higher in diabetes mellitus.According to the CTCAE classification, performing liver resection in the same session increased the risk of complications 5 times, while the use of open surgical technique increased the risk 8 times.Discussion: Neither classification system is superior to the other in grading postoperative complications, and both can be used to rate surgical complications.
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Özcan et al. (2022) conducted a cohort in Colorectal cancer (n=222). Clavien-Dindo classification vs. Common Terminology Criteria for Adverse Events (CTCAE) classification was evaluated on Early complication rates and risk factors. Both Clavien-Dindo and CTCAE classification systems can be used to rate surgical complications in colorectal cancer, with both identifying open surgery as increasing complication risk 8-fold.
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