Key result
Mental stress-induced peripheral vasoconstriction is linked to increased insula and decreased medial prefrontal cortex activation.
Why the study?
Does exposure to mental stress induce specific brain activation changes associated with peripheral vasoconstriction in patients with coronary artery disease?
Population
59 subjects with a history of coronary artery disease
Comparison
Exposure to mental stress tasks with concurrent… vs Control conditions
Design
Cross-sectional
Authors
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Highlights potential neural targets for stress vascular effects in CAD; hypothesis-generating and should not yet change practice.
Observational (n=59)
Does exposure to mental stress induce specific brain activation changes associated with peripheral vasoconstriction in patients with coronary artery disease?
p-value: p=<0.005
Stress-induced peripheral vasoconstriction in CAD patients is linked to altered activation in brain regions involved in emotion and autonomic regulation, highlighting potential central mechanisms of stress-induced vascular toxicity.
Shah et al. (2018) conducted an observational in Coronary artery disease (n=59). Mental stress vs. Control conditions was evaluated on Brain activation contrasts between groups above and below the median PAT ratio (p=<0.005). Mental stress-induced peripheral vasoconstriction was associated with increased activation in the insula and parietal cortex and decreased activation in the medial prefrontal cortex (cutoff p<0.005).
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