Key result
Preoperative L-FABP identifies ~80% of high-risk patients for AKI after cardiac surgery, elevating before NGAL.
Highlights the clinical challenge of acute kidney injury after cardiac surgery and the potential role of biomarkers for early detection.
May aid preoperative AKI risk stratification after cardiac surgery; hypothesis-generating and requires prospective validation before clinical adoption.
ncreasingly in high-risk patients for renal failure, such as those who are aged or have diabetes mellitus or hypertension, acute kidney injury (AKI) often complicates cardiac surgery.The prevalence of AKI has been reported as up to 30% in the postoperative period 1 and thus associated with an increase in short-term mortality, regardless of the severity of AKI. 2 AKI is also associated with long-term mortality.3 Therefore, preventing the development of AKI in such patients who undergo cardiac surgery has been a big challenge for us.
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Kohagura et al. (2011) conducted an editorial in Acute Kidney Injury after cardiac surgery. L-FABP biomarker was evaluated. Preoperative measurement of L-FABP could define approximately 80% of patients at high risk for developing acute kidney injury after cardiac surgery, elevating earlier than NGAL.
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