The Evolving Role of Novel Oral Agents for Testosterone Replacement Therapy; A Historical Perspective

There have been multiple attempts at an oral testosterone option for men with testosterone deficiency (TD), however many have been unsuccessful due to severe adverse reactions and lack of efficacy compared with other options. Due to a recent development in the pharmacology of delivery of oral testosterone through a self emulsifying drug delivery system, there has been the advent of new oral options for men suffering from TD. This review covers the history and challenges of oral testosterone, the development of a novel drug delivery system to allow men to absorb oral testosterone safely, and the efficacy of three oral testosterone options.—Jatenzo, Tlando and Kyzatrex. Clinicaltrials.gov identifier: NCT04467697.