Key result
Post-ICU multidisciplinary follow-up awaits final data to assess one-year quality of life improvements.
Why the study?
Critically ill patients are at risk of postintensive care syndrome which impacts quality of life, but no intervention has been shown to improve quality of life.
Does a post-ICU multidisciplinary follow-up improve quality of life at 1 year in critically ill patients?
RCT (n=546)
Blinded
Randomized
Yes
Does a post-ICU multidisciplinary follow-up improve quality of life at 1 year in critically ill patients?
This protocol describes an ongoing multicenter RCT assessing whether a multidisciplinary post-ICU follow-up improves quality of life at 1 year.
Efficacy of post-ICU multidisciplinary follow-up remains unknown; this RCT will deliver definitive evidence on 1-year quality of life.
BACKGROUND Critically ill patients are at risk of developing a postintensive care syndrome (PICS), which is characterized by physical, psychological, and cognitive impairments and which dramatically impacts the patient’s quality of life (QoL). No intervention has been shown to improve QoL. We hypothesized that a medical, psychological, and social follow-up would improve QoL by mitigating the PICS. OBJECTIVE This multicenter, randomized controlled trial (SUIVI-REA) aims to compare a multidisciplinary follow-up with a standard postintensive care unit (ICU) follow-up. METHODS Patients were randomized to the control or intervention arm. In the intervention arm, multidisciplinary follow-up involved medical, psychological, and social evaluation at ICU discharge and at 3, 6, and 12 months thereafter. In the placebo group, patients were seen only at 12 months by the multidisciplinary team. Baseline characteristics at ICU discharge were collected for all patients. The primary outcome was QoL at 1 year, assessed using the Euro Quality of Life-5 dimensions (EQ5D). Secondary outcomes were mortality, cognitive, psychological, and functional status; social and professional reintegration; and the rate of rehospitalization and outpatient consultations at 1 year. RESULTS The study was funded by the Ministry of Health in June 2010. It was approved by the Ethics Committee on July 8, 2011. The first and last patient were randomized on December 20, 2012, and September 1, 2017, respectively. A total of 546 patients were enrolled across 11 ICUs. At present, data management is ongoing, and all parties involved in the trial remain blinded. CONCLUSIONS The SUVI-REA multicenter randomized controlled trial aims to assess whether a post-ICU multidisciplinary follow-up improves QoL at 1 year. CLINICALTRIAL Clinicaltrials.gov NCT01796509; https://clinicaltrials.gov/ct2/show/NCT01796509 INTERNATIONAL REGISTERED REPORT DERR1-10.2196/30496
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Friedman et al. (2021) conducted an RCT in Postintensive care syndrome (PICS) (n=546). Multidisciplinary follow-up (medical, psychological, and social evaluation) vs. Standard post-ICU follow-up (seen only at 12 months) was evaluated on Quality of life at 1 year, assessed using the Euro Quality of Life-5 dimensions (EQ5D). The SUIVI-REA trial enrolled 546 critically ill patients to assess whether a post-ICU multidisciplinary follow-up improves quality of life at 1 year; data management is currently ongoing.
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