Taraxastane, oleanane, ursane, lupane, taraxane, cycloartane, dammarane and tirucallane triterpenoids isolated from flowers of Compositae plants have been previously reported to exhibit anti-inflammatory effects and are variously competitive and non-competitive inhibitors of the serine proteases trypsin and chymotrypsin. The general features of those triterpenoids found to be protease inhibitors are having a hydroxy group and an appropriate side chain in the region of the molecule distal to the 3-hydroxy group. However, fatty acid esterification of the triterpenoid 3-hydroxy group can have a marked effect on inhibitor effectiveness. This suggests a possible means of rapid alteration of the plant defensive complement in vivo and of the bioactivity of these anti-inflammatory compounds . Abbreviations BAPNA: N α -benzoyl-DL-arginine- p -nitroanilide BYPNA: N -benzoyl-L-tyrosine- p -nitroanilide PKA:cyclic AMP-dependent protein kinase TLCK: N -α- p -tosyl-L-lysinylchloromethyl ketone (1-chloro-3-tosylamido-7-amino-L-2-heptanone) TPCK: N -tosyl-L-phenylalanylchloromethyl ketone (L-(1-tosyl-amido-2-phenyl)ethylchloromethyl ketone).
No takes yet. Share an insight, caveat, or question.
Rajic et al. (2001) studied this question.