Key result
HIV infection in men is linked to higher epicardial fat volume compared to controls.
Why the study?
Is epicardial fat volume increased in HIV-infected men compared to HIV-negative controls, and is it associated with metabolic parameters?
Observational (n=110)
Is epicardial fat volume increased in HIV-infected men compared to HIV-negative controls, and is it associated with metabolic parameters?
Answers are grounded in this paper and cite their sources.
Epicardial fat volume is increased in HIV-infected men and correlates independently with metabolic risk factors such as fasting glucose and insulin.
Epicardial fat accumulation may have important clinical consequences, yet little is known regarding this depot in HIV patients. We compared epicardial fat volume in 78 HIV-infected men and 32 HIV-negative controls. Epicardial fat volume was higher in HIV-infected patients than that in controls (P = 0.04). In HIV patients, epicardial fat volume was strongly associated with visceral adipose tissue area (rho = 0.76, P < 0.0001), fasting glucose (rho = 0.41, P = 0.001) and insulin (rho = 0.44, P = 0.0003). Relationships with glucose and insulin remained significant controlling for age, race, BMI, adiponectin, visceral adipose tissue and antiretroviral therapy. Epicardial fat may be an important fat depot in HIV-infected patients.
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Lo et al. (2010) conducted an observational in HIV infection (n=110). HIV infection vs. HIV-negative controls was evaluated on Epicardial fat volume (p=0.04). HIV infection in men was associated with higher epicardial fat volume compared to controls (P=0.04), which correlated strongly with visceral adipose tissue, fasting glucose, and insulin.
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