HIV-infected patients with HAART-associated metabolic syndrome and lipodystrophy had higher epicardial fat thickness (8 vs 6.5 mm, p<0.01) and IMT (0.71 vs 0.66 mm, p<0.01) than those without.
Cross-Sectional (n=105)
Is echocardiographic epicardial fat thickness related to visceral adiposity and carotid intima-media thickness in HIV-infected patients on HAART with metabolic syndrome and lipodystrophy?
Echocardiographic assessment of epicardial fat may serve as a simple and reliable marker of visceral adiposity and increased cardiovascular risk in HIV-infected patients with HAART-associated metabolic syndrome.
Tasa de eventos absoluta: 8% vs 6.5%
valor p: p=<0.01
BACKGROUND: High cardiovascular risk and accelerated atherosclerosis are associated with human immunodeficiency virus (HIV). Recently, the use of highly active antiretroviral therapy (HAART) for the treatment of HIV infection is correlated with the development of HAART-associated metabolic syndrome and lipodystrophy (LDS). Detection of epicardial fat thickness, new index of visceral adiposity in non HIV-infected patients, might be important as diagnostic tool in HIV-infected patients on HAART. OBJECTIVE: Primary objective of this study was to evaluate whether echocardiographic epicardial adipose tissue is related to visceral adipose tissue (VAT) and Carotid Intima-Media Thickness (IMT), index of atherosclerosis in HIV-infected patients on HAART with LDS. DESIGN: We studied 60 consecutive HIV-infected subjects with HAART-associated metabolic syndrome and LDS and 45 HIV-infected subjects on HAART without LDS. MAIN OUTCOMES MEASURES: Epicardial fat thickness and IMT were measured by ultrasonography in both study and control groups. Magnetic resonance imaging (MRI) was used to calculate VAT in HIV-infected subjects on HAART with LDS. RESULTS: Epicardial adipose tissue thickness showed an excellent correlation with MRI-VAT (r=0.85; P<0.001) and IMT (r=0.78;P<0.001) in HIV-infected patients on HAART-with LDS. Multiple regression analysis showed that epicardial fat thickness was best predicted by MRI-VAT and IMT (R2=0.57, p<0.001 and p<0.01, respectively). HIV-infected patients with HAART-associated metabolic syndrome and LDS showed higher epicardial fat thickness and IMT (8 vs 6.5 mm; 0.71 vs 0.66 mm, respectively, p<0.01 for both) than HIV-infected subjects on HAART without LDS. CONCLUSION: Echocardiographic assessment of epicardial fat may have the potential to be a simple and reliable marker of visceral adiposity and increased cardiovascular risk in HIV-infected patients with HAART-associated metabolic syndrome and LDS.
Iacobellis et al. (Thu,) conducted a cross-sectional in HIV infection with HAART-associated metabolic syndrome and lipodystrophy (n=105). HAART-associated metabolic syndrome and lipodystrophy vs. HIV-infected subjects on HAART without lipodystrophy was evaluated on Epicardial fat thickness (mm) (p=<0.01). HIV-infected patients with HAART-associated metabolic syndrome and lipodystrophy had higher epicardial fat thickness (8 vs 6.5 mm, p<0.01) and IMT (0.71 vs 0.66 mm, p<0.01) than those without.