Key result
MOF-based nanoplatforms show a volcano-type trend in ROS scavenging efficiency and enable real-time feedback.
Why the study?
Traditional diagnostic and therapeutic methods for inflammation separate monitoring and treatment, making dynamic tracking and precise intervention difficult to achieve.
MOF-based nanoplatforms with size-dependent ROS scavenging and fluorescence properties offer a potential new strategy for real-time monitoring and treatment of inflammation.
Size-optimized MOF nanoplatforms may enable theranostic inflammation management; hypothesis-generating in animal models, requiring clinical validation.
Traditional diagnostic and therapeutic methods for inflammation are hindered by the separation of monitoring and treatment, making dynamic tracking and precise intervention difficult to achieve. To address these issues, this study constructed a series of metal-organic framework (MOF)-based nanoplatforms of varying sizes that integrate multiphoton excited fluorescence imaging, reactive oxygen species (ROS) scavenging, and targeted delivery functions. The results showed that the ROS scavenging efficiency of the resulting samples followed a "volcano-type" trend with changes in particle size. Moreover, the multiphoton excited fluorescence performance also varied dynamically with particle size, enabling real-time feedback on the ROS scavenging process. This study provides a new strategy for the diagnosis and treatment of inflammation.
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Yang et al. (2026) studied Inflammation. Metal-organic framework (MOF)-based nanoplatforms was evaluated on ROS scavenging efficiency and multiphoton excited fluorescence performance. Metal-organic framework (MOF)-based nanoplatforms demonstrated a 'volcano-type' trend in ROS scavenging efficiency with changes in particle size, enabling real-time feedback on the scavenging process.
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