Key result
Four polyphenols from Prunus armeniaca demonstrated potential ACE2 inhibitory activity in silico, and the aqueous extract was safe in an in vivo acute toxicity study.
Why the study?
SARS-CoV-2 uses ACE2 to enter host cells, motivating the evaluation of polyphenols from Prunus armeniaca for potential ACE2 inhibitory activity.
Four polyphenols from Prunus armeniaca demonstrate potential in silico inhibition of ACE2, with the aqueous extract showing safety in vivo.
BACKGROUND: SARS-CoV-2 is a virus that uses ACE2 to enter the host cell. AIMS AND OBJECTIVES: This study aimed to evaluate the in silico inhibitory activity of polyphenols from Prunus armeniaca (P. armeniaca) on angiotensin-converting enzyme 2 (ACE2). METHODS: The efficacy of phytocompounds from P. armeniaca in inhibiting ACE2 was tested through molecular docking and dynamic analyses. The toxicological analysis of P. armeniaca was also evaluated. RESULTS: A total of twenty polyphenols were docked against the ACE2 active site, and four compounds showed interesting profiles. In vivo acute toxicity study demonstrated that the aqueous extract of Prunus armeniaca was safe. CONCLUSION: Four compounds from Prunus armeniaca seem to exert an inhibitory potential of ACE2.
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Bouadid et al. (2023) studied SARS-CoV-2 / ACE2 inhibition. Polyphenols from Prunus armeniaca was evaluated on ACE2 inhibitory activity and in vivo acute toxicity. Four polyphenols from Prunus armeniaca demonstrated potential ACE2 inhibitory activity in silico, and the aqueous extract was safe in an in vivo acute toxicity study.
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