Key result
AMI-CS survivors have ~85% higher one-year mortality versus no shock, mitigated by excellent inpatient care.
Why the study?
Long-term outcomes of acute myocardial infarction with cardiogenic shock survivors and the influence of inpatient care quality were unclear.
Does cardiogenic shock and inpatient care quality impact long-term mortality in acute myocardial infarction survivors?
Population
330,517 UK AMI patients, excluding those dying within thirty-days
Comparison
AMI-CS survivors vs AMI without CS, and levels of inpatient care quality
Design
Nationwide registry-based cohort study
Follow-up
Median 1642 days
Authors
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May warrant closer long-term surveillance for AMI-CS survivors; leaves open whether post-discharge interventions extend benefits seen with high-quality inpatient care.
Cohort (n=330,517)
Yes
Does cardiogenic shock and inpatient care quality impact long-term mortality in acute myocardial infarction survivors?
Hazard Ratio: 1.85 (95% CI 1.68–2.04)
p-value: p=<0.001
Survivors of AMI with cardiogenic shock have a persistently elevated risk of long-term mortality up to 5 years compared to those without shock, though higher-quality inpatient care significantly improves long-term survival.
Weight et al. (2024) conducted a cohort in Acute myocardial infarction with cardiogenic shock (n=330,517). Cardiogenic shock vs. No cardiogenic shock was evaluated on One-year mortality (HR 1.85, 95% CI 1.68-2.04, p=<0.001). AMI-CS survivors had a higher risk of one-year mortality than those without shock (HR 1.85; 95% CI 1.68-2.04), though excellent inpatient care reduced long-term mortality risk (HR 0.46).
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