What is the clinical evidence from this study?

Study design: Observational. Population: Cardiogenic shock following acute myocardial infarction (n=16). Intervention: Intra-aortic balloon pumping (IABP). Primary outcome: Weaned from IABP.

What question did this study set out to answer?

To evaluate the hemodynamic and electrocardiographic effects of intra-aortic balloon pumping in animal models and clinical cases of post-infarction cardiogenic shock.

August 1, 1979Artificial Organs

Experimental and Clinical Studies on the Effect of Intra‐Aortic Balloon Pumping for Cardiogenic Shock Following Acute Myocardial Infarction

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Key result

Intra-aortic balloon pumping allowed 37.5% (6 of 16) of patients with cardiogenic shock secondary to acute myocardial infarction to be successfully weaned from the device.

Why the study?

Does intra-aortic balloon pumping improve hemodynamics and clinical outcomes in cardiogenic shock following acute myocardial infarction?

Population

Dogs with experimentally induced cardiogenic shock and 16 patients with cardiogenic shock secondary to acute…

Design

Other

Authors

MOMasayoshi OkadaKurashiki University of Science and the Arts TSTakuo ShiozawaKobe University MIMasashi IizukaOsaka City University

Discussion

Member takes

Implication

May support IABP weaning in select post-MI shock cases; leaves open efficacy in randomized trials.

Key Points

To evaluate the hemodynamic and electrocardiographic effects of intra-aortic balloon pumping in animal models and clinical cases of post-infarction cardiogenic shock.
Induced cardiogenic shock in canine models through multiple coronary artery ligations, including subgroups modeling secondary ventricular septal defect (VSD) and mitral regurgitation (MR).
Administered intra-aortic balloon pumping (IABP) clinically in 16 patients with post-infarction cardiogenic shock and evaluated 3 autopsied cases to correlate outcomes with infarct size.
Canine models demonstrated improved hemodynamics and electrocardiographic tracings via diastolic augmentation and systolic unloading, but showed no benefit when left ventricular free wall infarction exceeded 50%.
IABP provided significant hemodynamic improvement in mechanical complications unless the pulmonary-to-systemic flow ratio exceeded 4.5 in VSD or mean left atrial pressure exceeded 30 mmHg in MR.
In the clinical cohort of 16 patients presenting with cardiogenic shock secondary to acute myocardial infarction, 6 patients (37.5%) were successfully weaned from IABP support.

Study Design

Type

Observational (n=16)

Structured PICO

Does intra-aortic balloon pumping improve hemodynamics and clinical outcomes in cardiogenic shock following acute myocardial infarction?

Population

16 patients with cardiogenic shock secondary to acute myocardial infarction treated with intra-aortic balloon pumping.

Intervention

Intra-aortic balloon pumping (IABP)

Outcome

Hemodynamic and electrocardiographic changes, and successful weaning from IABPsurrogate

IABP provides hemodynamic and electrocardiographic improvement in cardiogenic shock post-MI, though efficacy is limited in cases of massive infarction or severe mechanical complications.

Cite This Study

Okada et al. (1979) conducted an observational in Cardiogenic shock following acute myocardial infarction (n=16). Intra-aortic balloon pumping (IABP) was evaluated on Weaned from IABP. Intra-aortic balloon pumping allowed 37.5% (6 of 16) of patients with cardiogenic shock secondary to acute myocardial infarction to be successfully weaned from the device.

synapsesocial.com/papers/6aa443c404de40c43bb15b6a https://doi.org/10.1111/j.1525-1594.1979.tb01062.x

Topics

Mitral valve intervention

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