Key result
Patients with coronary artery disease and/or type 2 diabetes mellitus had significantly elevated serum levels of IL-6 and decreased levels of IGF-1 compared to healthy controls.
Why the study?
The study was conducted to investigate the association between proinflammatory cytokines, specifically IL-6, and IGF-1 levels in CAD and T2DM.
Cross-Sectional (n=90)
No
Absolute Event Rate: 479.87% vs 137.38%
p-value: p=<0.05
Elevated IL-6 and decreased IGF-1 levels are associated with coronary artery disease and type 2 diabetes mellitus, supporting the role of inflammation in cardiovascular and metabolic disease pathogenesis.
Objective: The objective of this study was to investigate the association between proinflammatory cytokines in special, the interleukin-6 (IL-6), and insulin-like growth factor (IGF-1) levels in coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM).Methods: This study was conducted from November 2017 to March 2018 in Anbar, Iraq. We studied a total of 90 individuals (46 men and 44 women) aged between 20 and 87 years. The samples were divided into four groups: CAD patients (n=23), T2DM patients (n=23), coronary artery disease and type 2 diabetes together in the same patient (n=23), and control group (n=21). The concentrations of IL-6 and IGF-1 were determined using a commercially available enzyme-linked immune sorbent assay.Results: The results of the present study showed that there were elevated serum levels of IL-6 and low levels of IGF-1 in all the tested groups, compared with the control. The difference was statistically significant at p<0.05. The results showed a positively correlated between IL-6 and IGF-1 in the CAD group and T2DM group, while it was a negative correlation between serum levels of IL-6 and IGF-1 in the T2DM+CAD group.Conclusion: Elevated levels serum of IL-6 predicts the development of CAD and T2DM. These data support a possible role for inflammation in diabetogenesis and complication of the cardiovascular disease. There is an inverse relationship between the levels serum of IGF-1 and increased risk of CAD and development of T2DM.
No takes yet. Share an insight, caveat, or question.
Al-okhedi et al. (2018) conducted a cross-sectional in Coronary Artery Disease and Type 2 Diabetes Mellitus (n=90). Coronary artery disease and/or Type 2 diabetes mellitus vs. Healthy controls was evaluated on Serum levels of IL-6 (pg/ml) (p=<0.05). Patients with coronary artery disease and/or type 2 diabetes mellitus had significantly elevated serum levels of IL-6 and decreased levels of IGF-1 compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: