Key result
The ACE II genotype showed no overall association with migraine, but was protective against migraine with aura in the Turkish population (OR 0.366; 95% CI 0.137-0.980).
Why the study?
Does the ACE insertion/deletion polymorphism associate with the risk of migraine?
Meta-Analysis (n=30,324)
Does the ACE insertion/deletion polymorphism associate with the risk of migraine?
While there is no overall association between the ACE I/D polymorphism and migraine, the II genotype may exert a protective effect against migraine in the Turkish population.
Does not support ACE genotyping for migraine risk; leaves open ethnicity-specific protective effects against aura.
BACKGROUND: Many studies investigated the association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and migraine, with controversial results. Thus, we performed a meta-analysis to better evaluate the correlation of this polymorphism and migraine. METHODS: We retrieved studies published up to September 2014 about the ACE gene polymorphism and migraine from electronic database. Pooled odds ratios (ORs) with 95% confidence interval (CI) were calculated to examine the strength of association between the ACE I/D polymorphism and migraine, using random-effects models. RESULTS: We identified 14 separate studies, in which 7334 migraineurs and 22 990 healthy controls were eligible for the meta-analysis. The results showed no relationship between the ACE I/D polymorphism and any migraine. Stratification revealed a protective effect in the Turkish population against migraine with aura for the II genotype model (II vs. DD: pooled OR = 0.366, 95% CI = 0.137-0.980; II vs. DI + DD: pooled OR = 0.370, 95% CI = 0.145-0.945). Similar results were obtained for Turkish people with migraine without aura (II vs. DD: pooled OR = 0.386; 95% CI = 0.166-0.900; II vs. DI + DD: pooled OR = 0.347; 95% CI = 0.156-0.773). CONCLUSIONS: The data suggest that the ACE II genotype could exert a protective effect against migraine with aura and without aura at least in the Turkish population.
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Wan et al. (2015) conducted a meta-analysis in Migraine (n=30,324). ACE insertion/deletion (I/D) polymorphism (II genotype) vs. DD or DI + DD genotypes was evaluated on Migraine with aura (II vs. DD genotype in Turkish population) (OR 0.366, 95% CI 0.137-0.980). The ACE II genotype showed no overall association with migraine, but was protective against migraine with aura in the Turkish population (OR 0.366; 95% CI 0.137-0.980).
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