Key result
Relative bradycardia in septic shock linked to ~38% lower 28-day mortality versus never-bradycardic patients.
Why the study?
Does relative bradycardia improve 28-day mortality in adult patients with septic shock requiring vasopressors?
Population
1,554 adult patients with septic shock requiring vasopressors admitted to ICUs during 2005-2013
Comparison
Relative bradycardia (heart rate < 80 beats/min) vs Never-bradycardic group
Design
Cohort
Follow-up
28 days
Authors
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Relative bradycardia was associated with lower mortality in vasopressor-treated septic shock; hypothesis-generating and should not change practice without randomized trials.
Cohort (n=1,554)
Yes
Does relative bradycardia improve 28-day mortality in adult patients with septic shock requiring vasopressors?
Absolute Event Rate: 21% vs 34%
p-value: p=<0.001
Relative bradycardia (heart rate < 80 beats/min) in patients with septic shock requiring vasopressors is associated with significantly lower 28-day mortality.
Beesley et al. (2016) conducted a cohort in Septic shock (n=1,554). Relative bradycardia (heart rate < 80 beats/min) vs. Never-bradycardic was evaluated on 28-day mortality (p=<0.001). Relative bradycardia in patients with septic shock was associated with lower 28-day mortality compared to never-bradycardic patients (21% vs 34%; p < 0.001).
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