Key result
Whole-genome sequencing of the first Indian African Swine Fever Virus isolate assigned it to genotype II and clade 1.1.1, highlighting its genetic distinctiveness and evolutionary path.
Why the study?
African swine fever is a major threat with no vaccine or therapy, and following its first reported incidence in India in May 2020, the whole genome of an Indian isolate had not been sequenced.
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The first whole genome sequence of an Indian isolate of African Swine Fever Virus provides insights into its genetic diversity and molecular evolution.
African swine fever (ASF) was first reported in 1921, and since then has posed a major threat to the world pig industry and still remains a major challenge as there is no vaccine or therapy available. In May 2020, the first incidence of ASF was recorded in India, followed by a number of outbreaks in the north eastern part of India. In this study, we report the first whole genome of an Indian isolate of ASF virus (ASF/IND/20/CAD/543) using next generation sequencing and compared with the other ASFV complete genome. On phylogenetic analysis, the virus was assigned to genotype II on the basis of p72 genotyping. However, the whole genome based phylogeny distinguished it from other genotype II isolates of clade 1.1.1. This study adds to our understanding of ASFV’s genetic diversity and molecular evolution.
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Mahajan et al. (2022) studied African swine fever (n=12). Whole genome sequencing of ASFV isolate vs. Other global ASFV complete genomes was evaluated on Genomic characterization and phylogenetic assignment. Whole-genome sequencing of the first Indian African Swine Fever Virus isolate assigned it to genotype II and clade 1.1.1, highlighting its genetic distinctiveness and evolutionary path.
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