Answers are grounded in this paper and cite their sources.
20-Deoxy-20-fluorocamptothecin (2) has been synthesized as an isosteric analogue of camptothecin (1). The use of selectfluor or N-fluorobenzenesulfonimide for the electrophilic fluorination of 20-deoxycamptothecin (3) yields the target compound. Enantioselective fluorination of 3 was also achieved using our previously described cinchona alkaloids/selectfluor combination to provide both enantiomers of 2 with 88% ee and 81% ee, respectively.
No takes yet. Share an insight, caveat, or question.
Shibata et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: