Key result
UV-inactivated adenoviruses suppress cellular DNA synthesis with varying sensitivity across human, monkey, and hamster cells.
UV-inactivated adenoviruses suppress cellular DNA synthesis with varying sensitivity across human, monkey, and hamster cell lines.
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Does not support clinical use of UV-inactivated adenoviruses; leaves open cell-type specific mechanisms in mammalian systems.
It was shown previously that cellular DNA synthesis in growing human embryo kidney (HEK) cells was suppressed by ultraviolet(UV)-inactivated adenoviruses [6].A difference in sensitivity to suppression of cellular DNA synthesis has been found among HEK, green monkey kidney (GMK) and hamster embryo (Ham E) cells.The
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Yamashita et al. (1971) studied this question. Ultraviolet-inactivated adenoviruses suppress cellular DNA synthesis with varying sensitivity across human embryo kidney, green monkey kidney, and hamster embryo cells.
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