Key result
Superinfection with adenovirus 2 inhibits SV40 and BKV DNA synthesis in monkey and human cells, beginning during the early phase of the Ad2 lytic cycle.
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Ad2 superinfection inhibits papovavirus DNA synthesis, suggesting genomic competition for an early Ad2 protein essential for Ad2 replication but inhibitory to SV40.
Simian Virus 40 (SV40) DNA synthesis is inhibited in monkey cells by superinfection with adenovirus 2 (Ad2) and various non-defective Ad2-SV40 hybrid viruses. Similarly, BKV (a human papovavirus) DNA synthesis is inhibited in human cells by superinfection with Ad2. Kinetic studies indicate that inhibition begins during the early phase of the Ad2 lytic cycle. Superinfection with Ad2 does not significantly alter the formation of SV40 T antigen. Superinfection with Ad2 late in SV40 lytic cycle is less efficient in the inhibition of SV40 DNA synthesis, and the onset of Ad2 DNA synthesis is delayed, compared to superinfection early in the SV40 lytic cycle. These findings suggest that the Ad2 and SV40 genomes may compete to bind an early AD2 protein which is essential for Ad2 replication, but which blocks SV40 replication.
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Patch et al. (1981) studied this question. Superinfection with adenovirus 2 (Ad2) and non-defective Ad2-SV40 hybrid viruses was evaluated on Inhibition of SV40 and BKV DNA synthesis. Superinfection with adenovirus 2 inhibits SV40 and BKV DNA synthesis in monkey and human cells, beginning during the early phase of the Ad2 lytic cycle.
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