December 1, 1975Journal of VirologyOpen Access

Block to multiplication of adenovirus serotype 2 in monkey cells

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Population

Monkey cells infected with adenovirus 2 (Ad2)

Comparison

Coinfection with simian virus 40 (SV40) vs Infection with Ad2 alone

Design

Preclinical

Authors

DKDaniel F. KlessigRutgers, The State University of New Jersey CACarl W. AndersonSignum Computer (Germany)

Discussion

Member takes

Implication

Indicates post-transcriptional block in Ad2 replication in monkey cells; leaves open SV40's role in mRNA processing for further mechanistic studies.

Structured PICO

Population

Monkey cells infected with adenovirus 2 (Ad2)

Intervention

Coinfection with simian virus 40 (SV40)

Comparator

Infection with Ad2 alone

Outcome

Synthesis of Ad2 proteins and concentration of Ad2-specific RNAssurrogate

The block to adenovirus 2 multiplication in monkey cells appears to be at the RNA level, likely due to abnormal processing of specific adenovirus messages, which can be overcome by SV40 coinfection.

Cite This Study

Klessig et al. (1975) studied this question.

synapsesocial.com/papers/6a72e651a238d4636f543fcf https://doi.org/10.1128/jvi.16.6.1650-1668.1975

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Implication

Indicates post-transcriptional block in Ad2 replication in monkey cells; leaves open SV40's role in mRNA processing for further mechanistic studies.