Key result
High-dose methylprednisolone lowers MDA and AMH in spinal cord injury rats without improving histological damage.
Why the study?
Does high-dose methylprednisolone affect ovarian reserve and lipid peroxidation in rats with acute spinal cord injury?
Does high-dose methylprednisolone affect ovarian reserve and lipid peroxidation in rats with acute spinal cord injury?
p-value: p=<0.05
High-dose methylprednisolone administration for acute spinal cord injury may affect ovarian reserve and resolve lipid peroxidation in a rat model.
May affect ovarian reserve in rat SCI models; hypothesis-generating and should not change clinical practice.
This study was conducted to investigate the hormonal and histological changes in the ovaries with high doses of methylprednisolone administration for acute spinal cord injury (SCI). Group I (trauma group, eight rats) were subjected to laminectomy and SCI but received no treatment. Group II (steroid group, eight rats) were subjected to SCI and received methylprednisolone (30 mg/kg, intraperitoneally). Group III (control group, six rats) underwent a sham operation without trauma and treatment. Malondialdehyde (MDA) levels were significantly decreased in Group II (p < 0.05). The scores of histopathological damage of the ovaries in the three groups were found to be statistically comparable (p > 0.05). Serum anti-Müllerian hormone (AMH) levels in the steroid group was significantly lower compared with the control group (p < 0.05). High-dose methylprednisolone administration may effect ovarian reserve with reversible ovarian damage and can resolve lipid peroxidation in rats with spinal cord injury.
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Osmanağaoğlu et al. (2013) studied acute spinal cord injury (n=22). methylprednisolone vs. no treatment or sham operation was evaluated on hormonal and histological changes in the ovaries (MDA, AMH, histopathological damage) (p=<0.05). High-dose methylprednisolone administration in rats with spinal cord injury significantly decreased MDA and serum AMH levels (p<0.05) with comparable histopathological damage scores (p>0.05).
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