Key result
Oral levofloxacin linked to polymorphic ventricular tachycardia with a normal QT interval.
Case Report (n=1)
This case highlights that oral levofloxacin can induce polymorphic ventricular tachycardia even in the presence of a normal QT interval.
May prompt consideration of levofloxacin in unexplained polymorphic VT with normal QT; hypothesis-generating for fluoroquinolone proarrhythmia beyond QT effects.
Polymorphic ventricular tachycardia (PVT) is a form of ventricular tachycardia characterized by QRS complexes that seem to change direction during the tachycardia. If associated with a prolonged QT interval, it is called torsades de pointes. In the absence of a congenital long QT syndrome, torsades is seen with certain drugs such as antiarrhythmic agents (Class IA, IC, III), psychotropic medications, antidepressants, antihistamines, and electrolyte disturbances. We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.
No takes yet. Share an insight, caveat, or question.
Paltoo et al. (2001) conducted a case report in Polymorphic ventricular tachycardia with normal QT interval (n=1). Oral levofloxacin was evaluated on Polymorphic ventricular tachycardia with normal QT interval. Oral levofloxacin use was associated with the development of polymorphic ventricular tachycardia with a normal QT interval in the absence of other known etiologies.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: