Key result
Levothyroxine noncompliance links to TSH elevation of ~1161 mu/L and pituitary enlargement from thyrotroph hyperplasia.
Case Report (n=1)
Thyrotroph hyperplasia causing pituitary enlargement can occur in patients with protracted elevated TSH levels due to noncompliance with levothyroxine replacement.
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Clinicians should consider thyrotroph hyperplasia in nonadherent hypothyroid patients with pituitary enlargement; single case leaves open prevalence and management implications.
Johnston et al. (2013) conducted a case report in Thyrotroph hyperplasia (n=1). Levothyroxine noncompliance was evaluated. Noncompliance with Levothyroxine in a 20-year-old woman with hypothyroidism led to significantly elevated TSH levels (1160.9 mu/L) and pituitary enlargement due to thyrotroph hyperplasia.
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