Key result
PON1, CYP3A5, COL4A1, and PTGIR gene polymorphisms are linked to cardiovascular disease risk.
Why the study?
The study was conducted to decipher the inter-relationship of SNPs and miRNAs involved in the pharmacogenomics of clopidogrel on predisposition to cardiovascular diseases.
Do mirSNPs in clopidogrel metabolism genes predict cardiovascular disease risk?
Case-Control (n=796)
Do mirSNPs in clopidogrel metabolism genes predict cardiovascular disease risk?
Specific mirSNPs in clopidogrel metabolism genes, including PON1 and CYP3A5, are associated with increased risk of cardiovascular diseases.
Answers are grounded in this paper and cite their sources.
mirSNPs in clopidogrel-related genes may stratify CVD risk; hypothesis-generating and requires prospective validation before any clinical use.
Aim: The present study was conducted to decipher the inter-relationship of SNPs and miRNAs involved in pharmacogenomics of clopidogrel on predisposition to cardiovascular diseases (CVDs). Materials & methods: A case–control study was conducted on 410 cases and 386 controls to analyze the association of 13 mirSNPs on CVDs risk. Genotyping was performed by tetra-primer amplification refractory mutation system PCR and validated using Sanger DNA sequencing. miRNA expression analysis was performed using TaqMan assays. A meta-analysis was performed for PON1 rs662 with coronary artery disease. Results & conclusion: PON1 rs662, PON1 rs3917577, CYP3A5 rs15524, COL4A1 rs874204 and PTGIR rs1126510 polymorphisms showed association with CVDs. The miRNA hsa-miR-224-5p showed differential expression in the PON1 rs3917577 GG genotype. The meta-analysis showed the population-specific impact of PON1 rs662 on South Asian and Middle East populations.
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Sharma et al. (2020) conducted a case-control in Cardiovascular diseases (CVDs) (n=796). mirSNPs in clopidogrel metabolism genes vs. Controls without cardiovascular diseases was evaluated on Cardiovascular disease risk. Polymorphisms in PON1, CYP3A5, COL4A1, and PTGIR genes were associated with cardiovascular disease risk, with hsa-miR-224-5p showing differential expression in the PON1 rs3917577 GG genotype.
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