What question did this study set out to answer?

Synthesize existing evidence on the epidemiology, pathophysiological mechanisms, clinical consequences, and therapeutic management of depression across the chronic kidney disease spectrum.

June 22, 2026World Journal of NephrologyOpen Access

Depression in chronic kidney disease and dialysis: A psychonephrology narrative review

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Authors

MYMonika YadavSafdarjang Hospital AKAdarsh KumarSafdarjang Hospital APAbhinav PandeyInstitute of Chartered Financial Analysts of India University, Jaipur

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Implication

Narrative review reveals high depression rates in chronic kidney disease, highlighting the need for integrated psychonephrology care models.

Key Points

Synthesize existing evidence on the epidemiology, pathophysiological mechanisms, clinical consequences, and therapeutic management of depression across the chronic kidney disease spectrum.
Narrative review synthesizing biological, psychosocial, diagnostic, and clinical dimensions of depression in patients with chronic kidney disease.
Evaluated pathophysiological factors, diagnostic limitations of standard screening tools, and integrated pharmacological and non-pharmacological care approaches in hemodialysis and peritoneal dialysis settings.
Depression is highly prevalent but under-recognized in kidney disease because somatic uremic symptoms conceal psychological distress.
Biological drivers such as inflammation, neuroendocrine dysregulation, and uremic toxin accumulation interact with psychosocial burdens to worsen hospitalization rates, dialysis adequacy, nutritional status, and mortality.
Overcoming diagnostic limitations requires specialized screening approaches coupled with multidisciplinary care models combining medical and psychological therapies.

Cite This Study

Yadav et al. (2026) studied this question.

synapsesocial.com/papers/6aa45a93bafce3a3b1e39eba https://doi.org/10.5527/wjn.121696

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Implication

Narrative review reveals high depression rates in chronic kidney disease, highlighting the need for integrated psychonephrology care models.

Depression in chronic kidney disease and dialysis: A psychonephrology narrative review

Discussion

Member takes

Implication

Key Points

Cite This Study

Depression in chronic kidney disease and dialysis: A psychonephrology narrative review

Discussion

Member takes

Implication

Key Points

Cite This Study

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