Key result
Acute exercise equally regulates myokine levels in men with T2D and weight-matched controls.
Why the study?
Does acute exercise elicit similar myokine responses in men with type 2 diabetes compared to weight-matched controls?
Observational (n=27)
Does acute exercise elicit similar myokine responses in men with type 2 diabetes compared to weight-matched controls?
Acute exercise induces similar myokine responses in patients with type 2 diabetes and healthy controls, suggesting the potential metabolic benefits of these myokines remain intact in T2D.
Supports preserved myokine responses to acute exercise in T2D; hypothesis-generating and requires prospective trials before clinical inference.
Regular exercise plays an important role in the prevention and treatment of type 2 diabetes (T2D). The synthesis and secretion of myokines in response to contraction may contribute to the beneficial metabolic effects of exercise. However, some exercise-induced responses may be attenuated in T2D. Here, we investigated whether the effect of acute exercise on selected myokines are impaired in T2D. Skeletal muscle biopsies and blood samples were obtained from 13 men with T2D and 14 weight-matched, glucose-tolerant men before, immediately after and 3-h after acute exercise (60 min cycling) to examine muscle expression and plasma/serum levels of selected myokines. One-hour of exercise increased muscle expression of IL6, FGF21, ANGPTL4, CHI3L1, CTGF and CYR61, of which FGF21, ANGPTL4 and CHI3L1 increased further 3-h into recovery, whereas expression of IL6, CYR61, and CTGF returned to baseline levels. There was no immediate effect of exercise on IL15 expression, but it decreased 3-h into recovery. Plasma IL-6 increased robustly, whereas circulating levels of FGF21, ANGPTL4, IL-15, and CHI3L1 increased only modestly in response to exercise. All returned toward baseline levels 3-h into recovery except for plasma ANGPTL4, which increased further. No significant differences in these responses to exercise were observed between the groups. Our results demonstrate that muscle expression and circulating levels of selected known and putative myokines were equally regulated by acute exercise in patients with T2D and weight-matched controls. This suggests that the potential beneficial metabolic effects of these myokines are not impaired in patients with T2D.
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Sabaratnam et al. (2018) conducted an observational in Type 2 diabetes (n=27). Acute exercise (60 min cycling) vs. Weight-matched, glucose-tolerant men was evaluated on Muscle expression and plasma/serum levels of selected myokines. Acute exercise equally regulated muscle expression and circulating levels of selected myokines in men with type 2 diabetes and weight-matched controls.
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