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November 1, 1999Journal of the American College of CardiologyOpen Access

Comparison of ventricular pressure relaxation assessments in human heart failure

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Key result

Hybrid-logistic method yields more consistent fits than monoexponential models, avoiding ~20% artificial prolongation in DCM.

  • 15% to 25% prolongation
  • P<0.0001
  • n=66

Population

66 patients, including those with normal hearts, hypertrophic cardiomyopathy, and dilated cardiomyopathy.

Comparison

Assessment of ventricular pressure relaxation… vs Comparison between different mathematical models…

Design

Cross-sectional

Authors

HSHideaki SenzakiNihon Institute of Medical ScienceBFBarry FeticsRobin Medical (United States)CCChen-Huan ChenGeneral / Preventive / Lipids

Discussion

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Implication

Hybrid-logistic models may enhance relaxation assessment accuracy; hypothesis-generating in cross-sectional data and requires prospective validation.

Study Design

Type

Observational (n=66)

Structured PICO

P
Population
66 patients with normal, hypertrophic cardiomyopathy, or dilated cardiomyopathy hearts undergoing pressure-volume relation measurements.
E
Exposure
Assessment of ventricular pressure relaxation parameters using various mathematical models (monoexponential, hybrid logistic, linear, pressure halftime) during preload reduction or inotropic stimulation.
C
Comparator
Comparison between different mathematical models and across different patient groups (normal, HCM, DCM).
O
Outcome
Sensitivity and stability of relaxation parameters to data range manipulation, loading changes, and drug stimulation.surrogate

Main Result

Effect estimate: 15% to 25% prolongation

p-value: p=<0.0001

The hybrid-logistic method provides more consistent data fits for assessing ventricular pressure relaxation across normal, hypertrophic, and dilated myopathic hearts compared to monoexponential models.

Cite This Study

Senzaki et al. (1999) conducted an observational in Heart failure (hypertrophic and dilated cardiomyopathy) (n=66). Hybrid-logistic method vs. Monoexponential (ME) models was evaluated on Prolongation of T(D) and T(F) by deletion of 1-2 data points (15% to 25% prolongation, p=<0.0001). The hybrid-logistic method provided more consistent data fits across all heart types compared to monoexponential models, which showed 15-25% artificial prolongation in dilated cardiomyopathy (P<0.0001).

synapsesocial.com/papers/6aa4666e747792c686ab7839https://doi.org/10.1016/s0735-1097(99)00362-9

Topics

Hypertrophic cardiomyopathy
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An analysis of variability of left ventricular pressure decay1993 · 7 citations
  2. 2Left ventricular relaxation in the filling and nonfilling intact canine heart1986 · 227 citations
  3. 3Disparate Inotropic and Lusitropic Responses to Pimobendan in Conscious Dogs with Tachycardia-Induced Heart Failure1994 · 52 citations
  4. 4Loading Sequence Plays an Important Role in Enhanced Load Sensitivity of Left Ventricular Relaxation in Conscious Dogs With Tachycardia-Induced Cardiomyopathy1995 · 50 citations
  5. 5Logistic Time Constant of Isovolumic Relaxation Pressure–Time Curve in the Canine Left Ventricle1995 · 132 citations