Key result
Calmodulin-dependent phosphodiesterase isoenzymes from bovine brain, heart, and lung exhibit distinct kinetic properties and differential regulation by calmodulin and calcium.
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Bovine CaMPDE isoform differences highlight tissue-specific regulation; leaves open relevance to human cardiovascular signaling.
Sharma et al. (1994) studied this question. Calmodulin-dependent phosphodiesterase isoenzymes from bovine brain, heart, and lung exhibit distinct kinetic properties and differential regulation by calmodulin and calcium.
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