What question did this study set out to answer?

To characterize the clinical, radiographic, and pathological manifestations of a systemic bone disease occurring in very small premature infants.

December 1, 1971PEDIATRICS

Systemic Bone Disease Developing in Small Premature Infants

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Authors

NGN T GriscomBoston Children's Hospital JCJohnM. CraigBoston Children's Hospital ENEdward B. D. NeuhauserCedars-Sinai Medical Center

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Implication

Case series reports systemic bone disease and growth failure in small premature infants, indicating an underlying metabolic or nutritional deficiency.

Key Points

To characterize the clinical, radiographic, and pathological manifestations of a systemic bone disease occurring in very small premature infants.
Evaluated clinical histories and diagnostic roentgenograms of 3 very small premature infants who developed bone disease during their third month of life.
Assessed hematologic markers and performed post-mortem histological bone examinations on one infant who died of an unrelated congenital malformation.
Roentgenograms demonstrated diffuse porosis, rib fractures, epiphyseal separations, metaphyseal cupping, and extensive subperiosteal new bone formation.
Laboratory testing identified concurrent hypoproteinemia, anemia, and moderate-to-severe neutropenia across all three infants.
Histopathology confirmed failure of enchondral bone growth with relative sparing of intramembranous bone, with skeletal abnormalities slowly resolving spontaneously in the surviving infants.

Cite This Study

Griscom et al. (1971) studied this question.

synapsesocial.com/papers/6aa46bb03d8649a8032a14f2 https://doi.org/10.1542/peds.48.6.883

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Implication

Case series reports systemic bone disease and growth failure in small premature infants, indicating an underlying metabolic or nutritional deficiency.

Systemic Bone Disease Developing in Small Premature Infants

Discussion

Member takes

Implication

Key Points

Cite This Study

Systemic Bone Disease Developing in Small Premature Infants

Discussion

Member takes

Implication

Key Points

Cite This Study

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