Key result
Higher deceleration capacity is linked to ~75% greater vasovagal syncope risk regardless of age.
Why the study?
The study was conducted to evaluate autonomic nervous function in patients with vasovagal syncope and assess the diagnostic value of deceleration capacity and acceleration capacity.
Do deceleration capacity and acceleration capacity have diagnostic value for predicting syncope in patients with vasovagal syncope?
Case-Control (n=170)
No
Do deceleration capacity and acceleration capacity have diagnostic value for predicting syncope in patients with vasovagal syncope?
Odds Ratio: 1.746 (95% CI 1.389ā2.195)
p-value: p=<0.001
Deceleration capacity >9.0 ms and acceleration capacity -9.0 ms are potentially valuable indicators for diagnosing vasovagal syncope and monitoring cardiac autonomic nervous dysfunction.
May inform autonomic evaluation in suspected vasovagal syncope; hypothesis-generating and requires prospective validation before practice change.
Background: Deceleration capacity (DC) and acceleration capacity (AC) are used to characterize autonomic regulation. The purpose of this study was to evaluate the autonomic nervous function in patients with vasovagal syncope (VVS) and to evaluate the diagnostic value of DC and AC for VVS. Methods: A total of 94 consecutive patients with VVS [51.0 (38.0-60.0) years; 48 males] and 76 healthy subjects [53.0 (44.3-62.8) years; 46 males] were recruited as controls. The study compared DC, AC, and heart rate variability (HRV) in 24-h ECG, echocardiogram, and biochemical examinations between the two groups. Results: < .001] were independently associated with syncope. Mean HR was associated with syncope only in patients <60 years of age. Receiver operating characteristics (ROC) curves showed areas under curve (AUC) of DC/AC for predicting syncope are 0.755/0.765 with sensitivity of 56.4%/60.6% and specificity of 93.4%/88.2%. Conclusion: Patients with VVS exhibit higher DC and lower AC. Both DC and AC are independently correlated with syncope. A DC value >9.0 ms and an AC value -9.0 ms could potentially be valuable indicators for monitoring cardiac autonomic nervous dysfunction.
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Wang et al. (2024) conducted a case-control in Vasovagal syncope (n=170). Deceleration capacity (DC) vs. Healthy controls was evaluated on Vasovagal syncope (OR 1.746, 95% CI 1.389-2.195, p=<0.001). Higher deceleration capacity (OR 1.746) and lower acceleration capacity (OR 0.553) were independently associated with vasovagal syncope, demonstrating diagnostic value regardless of age.