New double-chain and gemini catanionic analogues of the glycolipid galβ 1 cer identified as a cell receptor of the HIV-1 virus were easily prepared in two steps from unprotected lactose. Due to their sugar moiety, these new catanionic surfactants were able to be cationized by sodium ions and therefore to be characterized in their monomeric forms by electrospray mass spectrometry. To our knowledge, this is the first time that catanionic surfactants have been directly observed, proving undoubtedly their existence as monomeric species. These new catanionic glycolipids showed interesting anti-HIV-1 activities, acting as monomeric analogues of galβ 1 cer. Finally, these new catanionic glycolipids were characterized by their surface active properties, by lamellar mesophases, and by their aptitude to spontaneously form vesicles.
No takes yet. Share an insight, caveat, or question.
Blanzat et al. (1999) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: