A Case of GBS Following Dengue Fever (DENV1) in a Tertiary Care Hospital in Bangladesh

Dengue fever is a viral infection due to flavivirus, an Arboviral infection, manifesting with fever, headache, arthralgia, skin rashes. It has been reported that it can involve brain directly causing encephalitis or can have indirect manifestations of both central nervous system (CNS) and peripheral nervous system (PNS). The first neurological manifestation of dengue fever was reported from Thailand in 1976 [9]. Dengue virus1 (DENV1) rarely causes Guillain-Barré Syndrome (GBS). The reported incidence of neurological involvement associated with DENV infection is about 5%, [2,3] and spans both the PNS and CNS. The neurological manifestations may be due to the presumed or proven to be directly related to DENV infection, or an indirect complication. The incidence of PNS involvement in dengue was found to be 9.25% in a prospective cohort study. [8] The incidence of GBS following dengue fever is uncommon. In Bangladesh, where healthcare resources are often limited, the burden of dengue encephalopathy and other neurological complication due to dengue fever presents unique challenges for both diagnosis and management. [5] GBS following DENV1 is rare. Here a case following DENV1 is described.