Key result
Rare late recurrence of juvenile granulosa cell tumor at 5 years highlights long-term surveillance needs.
Why the study?
Juvenile granulosa cell tumors rarely occur in patients over 30 years old or present with late recurrence, making late-onset and recurrent presentations poorly documented.
Case Report (n=1)
This case demonstrates that although rare, late recurrence of juvenile granulosa cell tumors can occur, suggesting the need for long-term surveillance.
Answers are grounded in this paper and cite their sources.
May warrant extended surveillance in juvenile granulosa cell tumor; leaves open optimal duration and protocols.
Juvenile granulosa cell tumors (JGCTs) are rare ovarian tumors with overall good prognoses. They differ from adult granulosa cell tumors (AGCTs), which are well known for late recurrence. Most JGCTs (～97%) occur in individuals <30 years old. We report a recurrent JGCT in a 40-year-old woman 5 years after initial presentation. The histological appearance and lack of 402C>G missense point mutation of FOXL2 gene (characteristic of AGCT but absent in JGCT) allowed differentiation from AGCT. This is the first comprehensive report of JGCT with late recurrence. Although rare, late recurrence of JGCT can occur; long-term surveillance is suggested.
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San et al. (2020) conducted a case report in Juvenile Granulosa Cell Tumor (n=1). Late recurrence of Juvenile Granulosa Cell Tumor was evaluated on Late recurrence. A 40-year-old woman experienced a rare late recurrence of a juvenile granulosa cell tumor 5 years after initial presentation, highlighting the need for long-term surveillance.
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