Ketone body β-hydroxybutyrate-mediated histone β-hydroxybutyrylation upregulates lipolysis and attenuates metabolic syndrome

This is the authors' abstract. We don't add key points for this paper.

This is the first study to demonstrate that exogenous β-hydroxybutyrate supplementation attenuates metabolic syndrome (MetS) and identifies histone β-hydroxybutyrylation-mediated chromatin remodeling as one of the mechanisms to upregulate the transcription of the lipid catabolic genes, Hmgcs2, Cyp2d4, Cyp2e1, and Acaa1b. Our work constitutes a strong foundation for the use of 1,3-butanediol as an alternative epigenetic therapeutic for individuals who are physically unable to achieve the MetS lowering benefits of lifestyle modifications such as exercise and intermittent fasting.