Key result
Carbamazepine withdrawal, dantrolene, and bromocriptine resolve neuroleptic malignant syndrome and hyperkalemic cardiac arrest.
Case Report (n=1)
Carbamazepine can cause Neuroleptic malignant syndrome presenting as hyperkalemic cardiac arrest in the post-operative period.
Alerts clinicians to rare carbamazepine-associated NMS with arrest in children; leaves open incidence and prevention in larger cohorts.
We report the case of a 7-year-old girl operated for craniopharyngioma who developed hyperkalemic cardiac arrest in the post-operative period. She was diagnosed as Neuroleptic malignant syndrome (NMS) and the causative drug was carbamazepine. It was essentially a diagnosis of exclusion, and treatment was mainly supportive in form of withdrawal of the neuroleptic medication (carbamazepine) and administration of dantrolene and bromocriptine. Although, relatively uncommon, NMS can be fatal. NMS presents a clinical challenge as the patient outcome depends on its prompt recognition and treatment.
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Ambulkar et al. (2012) conducted a case report in Neuroleptic malignant syndrome (n=1). Carbamazepine was evaluated on Hyperkalemic cardiac arrest and Neuroleptic malignant syndrome. Carbamazepine exposure in a 7-year-old girl led to neuroleptic malignant syndrome and hyperkalemic cardiac arrest, managed with drug withdrawal, dantrolene, and bromocriptine.
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