What question did this study set out to answer?

Determine the relative contributions of rhythmic food intake versus the autonomous hepatic circadian clock in orchestrating daily liver gene expression.

April 1, 2019Cell ReportsOpen Access

Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

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Authors

BGBen J. GreenwellTexas A&M University ATAlexandra J. TrottMitchell Institute JBJoshua R BeytebiereIllumina (United States)

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Implication

Animal experimental study demonstrates that rhythmic feeding drives liver transcriptome oscillations in mice, indicating feeding schedules overpower local circadian clocks.

Key Points

Determine the relative contributions of rhythmic food intake versus the autonomous hepatic circadian clock in orchestrating daily liver gene expression.
Assessed liver transcriptome oscillations in mice subjected to rhythmic versus arrhythmic feeding regimens.
Monitored the expression profiles of core circadian clock genes alongside key metabolic and signaling pathways across feeding schedules.
More than 70% of rhythmic genes across the mouse liver transcriptome lost cyclic expression under arrhythmic feeding conditions.
Core circadian clock genes maintained normal 24-hour oscillations despite the loss of feeding rhythmicity.
Arrhythmic feeding altered the timing of critical hepatic signaling and metabolic pathways without modifying the core cell-autonomous clock.

Cite This Study

Greenwell et al. (2019) studied this question.

synapsesocial.com/papers/6aa49889f197b883c13d5b0b https://doi.org/10.1016/j.celrep.2019.03.064

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Implication

Animal experimental study demonstrates that rhythmic feeding drives liver transcriptome oscillations in mice, indicating feeding schedules overpower local circadian clocks.

Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Rhythmic Food Intake Drives Rhythmic Gene Expression More Potently than the Hepatic Circadian Clock in Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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