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Abstract— —The synaptic vesicle fraction, M2, isolated from rat brain tissue contained acetylcholine, acetylcholine esterase activity, and gangliosides. The separation of M2 into several subfractions showed that the enriched synaptic vesicle subfraction, M2A, contained acetylcholine, but little acetylcholine esterase and ganglioside. The membrane subfraction, M2B, was enriched in the enzyme and ganglioside. Calcium ions facilitated the removal of membrane material from the synaptic vesicle fraction. In addition, the acetylcholine esterase of the synaptic vesicle fractions, M2 and M2A, frequently were activated by calcium ions as well as other cations.
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Trotter et al. (1969) studied this question.
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